MicroRNA-155 in the Heart

Silencing MicroRNA-155 Ameliorates

MicroRNA-155 in the Heart: The Right Time at the Right Place in the Right Cell.

Shhh! Silencing by microRNA-155.

Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and onco...

Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy.

RATIONALE In response to mechanical and pathological stress, adult mammalian hearts often undergo mal-remodeling, a process commonly characterized as pathological hypertrophy, which is associated with upregulation of fetal genes, increased fibrosis, and reduction of cardiac dysfunction. The molecular pathways that regulate this process are not fully understood. OBJECTIVE To explore the functi...

The Emerging Role of MicroRNA-155 in Cardiovascular Diseases

MicroRNAs have been demonstrated to be involved in human diseases, including cardiovascular diseases. Growing evidences suggest that microRNA-155, a typical multifunctional microRNA, plays a crucial role in hematopoietic lineage differentiation, immunity, inflammation, viral infections, and vascular remodeling, which is linked to cardiovascular diseases such as coronary artery disease, abdomina...